Dr. J.Gy. Papp




Name: JULIUS GYULA PAPP, MD,PhD,DSc,FESC, academician
           
( Dr. Papp Gyula )

Present position: Research Professor, Division of Cardiovascular Pharmacology; Professor, Department of Pharmacology & Pharmacotherapy, Albert Szent-Györgyi Medical Center, University of Szeged

Professional Address: Division of Cardiovascular Pharmacology,
Hungarian Academy of Sciences and University of Szeged
H-6701 SZEGED, Dóm tér 12., P.O.Box. 427 - Hungary

Telephone: +36-62-545-681
Mobile phone: +36-30-9535-688
Telefax:
+36-62-544-565
E-mail: papp.gyula@med.u-szeged.hu or papp@phcol.szote.u-szeged.hu
Home page: http://www.szote.u-szeged.hu/phcol/mktrs/pappjgy.htm

Date and place of birth: 29th August, 1937, Szigetvár (Hungary)
Marital status: married with two children (wife: Helen Németh MD, PhD, DSc; children: Andrea Papp MD, PhD and Eszter Papp MD)

EDUCATION
1955-61 University Medical School of Pécs, Hungary
1961 M.D. degree ("Sub auspiciis Rei Publicae Popularis" - with Gold Ring from the President of the Hungarian Republic)

POSTGRADUATE TRAINING AND SCIENTIFIC WORK

1961-1967 Departments of Internal Medicine (Cardiology) and Pharmacology
University Medical School of Pécs, Hungary
1965 Institute for Circulation Research, Berlin (for 6 months)
1968-1969, 1971, 1981
Laboratory of Cardiac Electrophysiology, Department of Pharmacology
University of Oxford (cooperation with E.M. Vaughan Williams) - International Fellow and Visiting Lecturer
1968 C.Sc.med. (Candidate of Medical Sciences, equivalent to Ph.D.), Hungarian Academy of Sciences, Budapest
1982 D.Sc.med. (Doctor of Medical Sciences, the highest Hungarian medical scientific degree), Hungarian Academy of Sciences, Budapest
1990 Visiting Professor, University of Paris

ACADEMIC CAREER
1961-1967
Assistant Professor, University Medical School of Pécs
1970-1979 Adjunct and Associate Professor, Medical University of Szeged
1979-1991 (Full) Professor, Medical University of Szeged
1991-2001 Professor and Chairman, Department of Pharmacology & Pharmacotherapy, Albert Szent-Györgyi Medical University, Szeged
1993-present Academician - Member of the Hungarian Academy of Sciences
2001-2007 Professor and Head, Division of Cardiovascular Pharmacology,
Hungarian Academy of Sciences and  University of Szeged; Professor, Department of Pharmacology & Pharmacotherapy, Faculty of Medicine, University of Szeged
2007 - present Research Professor, Division of Cardiovascular Pharmacology,
Hungarian Academy of Sciences and  University of Szeged

ACTIVITY IN INTERNATIONAL AND NATIONAL CARDIOLOGICAL, CARDIO-PHARMACOLOGICAL SCIENTIFIC, UNIVERSITY AND GOVERNMENTAL BODIES
1. World Heart Federation (WHF)
General Secretary (1999-2003)
President's Adviser for Eastern Europe (1997-present)
Co-author:
Impending global pandemic of cardiovascular diseases
('White Book') (1999-present)
Task Force on Cardiac Rehabilitation Education
(in cooperation with WHO) (1996-2001)
2. International Society and Federation of Cardiology (ISFC)
Drug Committee Member (1990-93)
3. International Society of Cardiovascular Pharmacotherapy (ISCP)
Executive Board Member (1997-2009)
Emeritus Board Member (2009-present)
First Vice President (1999-2001)
4. European Society of Cardiology (ESC)
Board Member (1984-94)
Councillor (1984-88)
Treasurer (1988-92)
Vice-President (1992-94)
Chairman:
Working Group on Drug Therapy in Cardiology (1992-94)
Research & Training Fellowship Committee (1992-94)
Member:
Scientific Committee (1984-96; 1999-2004)
Nucleus of the Working Group on Cardiovascular Pharmacology and Drug Therapy (1990-2004)
Nominating Committee (1996-1998)
5. International Cardiological Institute for Therapeutic Research (ICITR)
Board Member & Scientific Adviser (1986-1996)
6. Alpe Adria Association of Cardiology
President (1994-95); Executive Board Member (1992-1998)
7. Hungarian Society of Cardiology (HSC)
Board Member (1976-present)
President-Elect (1990-92)
President (1992-95)
Past President (1995-1998)
Honorary Life-President (1998-present)
Chairman:
Scientific Committee (1998-2004)
8. Hungarian National Heart Foundation
Board Member (1993-1998)
9. Hungarian Society of Experimental and Clinical Pharmacology
Honorary President (2006-present), President (2000-2001), Board Member (1983- ), Member (1967-present)
10. Hungarian Professional Council on Cardiology
Member (1992-2009)
11. Hungarian Academy of Sciences
Corresponding Member (1993-1998)
Full Member (1998-present)
Member of Committee for Drug Research & Pharmacotherapy (1974-present)
Member of Scientific Committee (2011-present)
12. Hungarian Ministry of Health
Chairman:
Ethics Committee for Clinical Pharmacology and Drug Trials (1996-2006)
Board Member:
Medical Research Council (1997-2006)
Chairman:
Committee for Experimental & Clinical Pharmacology, Drug Abuse and Addiction (1999-2009)
13. Albert Szent-Györgyi Medical University
Vice-Rector & Chairman of the Scientific Committee (1991-2001)
Professor (full 1979-present) & Department Chairman (1991-2001)
Chairman:
Committee for PhD & Habilitation (1994-2000)

14. University of Szeged
Chairman:
Committee for Habilitation (2000-2006)
Member:
Scientific Council (2004-present)
15. Division of Cardiovascular Pharmacology, Hungarian Academy of Sciences
      and University of Szeged

Professor & Head (2001-2007), Research Professor (2007-present)

MEMBERSHIP - PROFESSIONAL SOCIETIES / ASSOCIATIONS
American Heart Association, Council on Clinical Cardiology : International Fellow
Hungarian Society of Cardiology
European Society of Cardiology (Fellow: FESC)
International Academy of Cardiovascular Sciences (Fellow)
International Society for Heart Research
The New York Academy of Sciences
Hungarian Society for Experimental and Clinical Pharmacology
Deutsche Gesellschaft für Pharmakologie
British Pharmacological Society
Hungarian Physiological Society
Histamine Club
Royal Society of Medicine (London) (Fellow)
Corresponding Membership
Portuguese Society of Cardiology
Spanish Society of Cardiology
MEMBERSHIP - EDITORIAL BOARD OF SCIENTIFIC JOURNALS
Journal of Cardiovascular Pharmacology and Therapeutics (Co-editor) ( 1996-2009),Editorial Board Member (2009-present)
Cardiovascular Drugs and Therapy (Associate Editor) (1999-2001), Editorial Board Member (2001-04)
Basic Research in Cardiology (1989-92)
Cardioscience (1989-95)
Cor et Vasa (1993-2004)
European Cardiology Journal by Fax (1999-present)
European Heart Journal (1979-84)
Dialogues in Cardiovascular Medicine (1999-2008)
Pharmacology and Therapeutics (1983-92)
Archives internationales de Pharmacodynamie (1976-1990)
Cardiologia Hungarica (1976-2005)
Portuguese Journal of Cardiology (1990-present)
New Trends in Arrhythmias (1989-present)
Journal of Basic and Clinical Cardiology (1998-present)
Acta Physiologica Hungarica (1999-present)
Timely Topics in Medicine: Cardiovascular Diseases (Internet) (1997-present)
Current Atherosclerosis Reports - Hungarian Edition (2001-2006)
Current Opinion in Cardiology - Hungarian Edition (Chairman, Editorial Board) (2002-2006)
Orvosképzés (Medical Education - in Hungarian) (2002-present)
Acta Biologica Szegediensis (2000-present)
Heart Drug (2001-2006)
Cardiovascular Diabetology (2003-present)
Thérapie (2013-present)
 

HONOURS AND AWARDS
a) Cardiology and cardiovascular pharmacology
Medal from the European Society of Cardiology (1988 and 1994)
'Pro Societate' Medal from the Hungarian Society of Cardiology (1995)
Medal and Diploma from the Polish Society of Cardiology (1994)
Commemorative Medal from the Hungarian Society of Cardiology (2007)
Honorary Membership and Diploma of Merit from the
Czech Society of Cardiology (1995)
Croatian Society of Cardiology (1995)
Hellenic (Greek) Society of Cardiology (1993)
Italian Society of Cardiology (1996)
Romanian Society of Cardiology (1994)
Slovak Society of Cardiology (1994)
Slovenian Society of Cardiology (1996)
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Romanian Academy of Medical Sciences (1994)

b) Other awards
Széchenyi-Prize (1999)
Albert Szent-Györgyi Prize (1994)
Issekutz-Prize (1996)
Order of Merit, Hungarian Republic-Officer's Cross (1996)
Academic Niveau Prize (2002, 2009)
Batthyány-Strattmann Prize (2003)
Einthoven Medal of Distinction (2007)
Lőw Memorial Plaque (2009)
György Gábor Medal (2011)
Gold Medal, Hungarian Society of Cardiology (2011)
Klebelsberg-Price (2012)
Hungarian Order of Merit-Middle Cross (2012)
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Medal of Merit, European Society of Cardiology (1988, 1994)
White Rose Order, Finland (1995)
Gold Medal, Yugoslav Society of Cardiology (1989)
Medal of Merit, Polish Society of Cardiology (1994)
Hippocrates Award, England (2009)

 

Recent References on the Biographee
1) Walker M.J.A.:Antiarrhythmic Drug Research. British Journal of Pharmacoology 147.: S222-S231, 2006.
2) Wenner G., Marton J.: Publication effectiveness of a Hungarian cardiologist's research team in international comparison. Cardiol.Hung. 36.: 194-198, 2006.
3) Who's Who in Medicine and Healthcare. Marquis, New Providence (USA), 8th Edition, p. 1089, 2011-2012.
4) Who's Who in Science and Engineering. Marquis, New Providence (USA) 10th Edition, p. 1378, 2008-2009.
5) Who's Who in the World. Marquis, New Providence (USA) 29th Edition, pp. 1836-1837, 2012.
6) Varró A., Moffat T.: Fifthy years in cardiovascular research and education . Cardiovascular (CV) Network 11:5, 2012.
7) Who's Who in the World. Marquis, New Providence (USA) 30th Edition, p. 1822,  2013.
8) Salamon F.: The world did not 'commence' in 2010 (in Hungarian) Courier (Szigetvár) 4.: 4-5, 2013

Publication records:
326 full papers in journals
[249 in foreign (English, German or French) languages] on cardiology, cardiovascular pathophysiology and pharmacology, the cumulative impact factor of which is 604.938 (34.7 before 1974). The total number of references to publications, including books and book-chapters amounts to 7494 out of which  6185 references are independent. Hirsch index: 43. g index:74.


Author or editor of 22 books; author of 24 book-chapters, 28 book-articles and 16 patents relating to cardio-vasoactive agents.

Selected full papers:

Papp JGy, Szekeres L: Analysis of the mechanism of adrenergic actions on ventricular vulnerability.
Eur. J. Pharmacol.
3:15-26, 1968.

Papp JGy, Szekeres L: The arrhythmogenic action of sympathomimetic amines.
Eur. J. Pharmacol.
3:4-14, 1968.

Papp JGy, Vaughan Williams EM: The effect of bretylium on intracellular cardiac action potentials in relation to its anti-arrhyhtmic and local anaesthetic activity.
Br. J. Pharmacol.
37:380-390, 1969.

Papp JGy, Vaughan Williams EM: A comparison of the anti-arrhythmic actions of I.C.I. 50172 and (-)propranolol and their effects on intracellular cardiac action potentials and other features of cardiac function.
Br.J.Pharmacol.
37:391-399, 1969.

Freedberg AS, Papp JGy, Vaughan Williams EM: The effect of altered thyroid state on atrial intracellular potentials.
J. Physiol. (London)
207:357-369, 1970.

Papp JGy: Autonomic responses and neurohumoral control in the human early antenatal heart.
Basic Res. Cardiol.
83:2-9, 1988

Udvary É, Papp JGy, Végh Á: Cardiovascular effects of the calcium sensitizer, levosimendan, in heart failure induced by rapid pacing in the presence of aortic constriction.
Br. J. Pharmacol.
114:656-661, 1995.

Édes I., Kiss É, Kitada Y, Powers FM, Papp JGy, Kranias EG, Solaro RJ: Effects of levosimendan, a cardiotonic agent targeted to troponin C, on cardiac function and on phosphorylation and Ca2+ sensitivity of cardiac myofibrils and sarcoplasmic reticulum in guinea pig heart.
Circ. Res. 77:107-113, 1995

Papp JGy, Németh M, Krassói I, Mester L, Hála O, Varró A: Differential electrophysiological effects of chronically administered amiodarone on canine Purkinje fibers versus ventricular muscle.
J. Cardiovasc. Pharmacol. Therapeut. 1:287-296, 1996.

Baczkó I., Leprán I., Papp JGy: KATP channel modulators increase survival rate during coronary occlusion-reperfusion in anaesthetized rats.
Eur.J. Pharmacol.
324:77-83, 1997.

Papp JGy: Positive inotropy by calcium sensitization - an evolving approach for the treatment of end-stage heart failure.
Am.J.Cardiol.
83:1(I)-3(I), 1999.

Baláti B, Varró A, Papp JGy: Pharmacological modification of the dispersion of repolarization in the heart: importance of the M cells.
Cardiovasc. Drugs Ther.
13:491-505, 1999.

Kis A, Végh Á, Papp JGy, Parratt JR: Pacing induced delayed protection against arrhythmias is attenuated by aminoguanidine, an inhibitor of nitric oxide synthase.
Br.J. Pharmacol.
127:1545-1555, 1999

Varró A, Baláti B, Iost N, Takács J, Virág L, Lathrop DA, Lengyel Cs, Tálosi L, Papp JGy: The role of the delayed rectifier component IKs in dog ventricular muscle and Purkinje fibre.
J. Physiol. (London) 523:67-81, 2000.

Virág L, Iost N, Opincariu M, Szécsi J, Bogáts G, Szenohradszky P, Varró A, Papp JGy: The slow component of the delayed rectifier potassium current in undiseased human ventricular myocytes.
Cardiovasc. Res.
49:790-797, 2001.

Csete K, Barzó P, Bodosi M, Papp JGy: Influence of nitrovasodilators and cyclooxygenase inhibitors on cerebral vasoreactivity in conscious rabbits.
Eur. J. Pharmacol.
412:301-309, 2001.

Opincariu M, Varró A, Iost N, Virág L, Hála O, Szolnoki J, Szécsi J, Bogáts G, Szenohradszky P, Mátyus P, Papp JGy: The cellular electrophysiological effect of a new amiodarone-like antiarrhythmic drug GYKI 16638 in undiseased human ventricular muscle: comparison with sotalol and mexiletine.
Current Medicinal Chemistry
9:41-46, 2002.

Biliczki P, Virág L, Iost N, Papp JGy, Varró A: Interaction of different potassium channels in cardiac repolarization in dog ventricular preparations: role of repolarization reserve.
Br. J. Pharmacol. 137:361-368, 2002.

Zicha S, Moss I, Varró A, Papp JGy, Dumaine R, Antzelevich C, Nattel S : Molecular basis of species-specific expression of repolarizing K+ currents in the heart.
Am.J. Physiol.
285:H1641-1649, 2003

Papp JGy, Singh BN : Atrial fibrillation: emerging possibilities for drug treatment: an overview of current opportunities and recent developments.
J. Cardiovasc. Pharmacol. Ther. 8S-I : S3, 2003

Leprán I, Papp JGy : Effect of long-term oral pretreatment with levosimendan on cardiac arrhythmias during coronary occlusion in conscious rats. Eur.J. Pharmacol. 464:171-176, 2003

Mátyus P, Varga I, Reggeti T, Simay A, Kállai N, Károlyházy L, Kocsis Á, Pémes I, Papp JGy : Novel antiarrhythmic compounds with combined class IB and class IIIB mode of action.
Current Medicinal Chemistry
11:61-69, 2004.

Nagy ZsA, Virág L, Tóth A, Biliczki P, Acsai K, Bányász T, Nánási P, Papp JGy, Varró A : Selective inhibition of sodium-calcium exchanger by SEA-0400 decreases early and delayed afterdepolarization in canine heart.
Br. J. Pharmacol.
143:827-831, 2004.

Lengyel Cs, Dézsi L, Biliczki P, Horváth Cs, Virág L, Jost N, Németh M, Tálosi L, Papp JGy, Varró A : Effect of a neuroprotective drug, eliprodil on cardiac repolarization : importance of the decreased repolarization reserve in the development of proarrhythmic risk.
Br. J. Pharmacol.
143:152-158, 2004.

Hõhn J, Pataricza J, Petri A, Gábor K, Balogh Á, Varró A, Papp JGy: Levosimendan interacts with potassium channel blockers in human saphenous vein.
Pharmacol. Toxicol. 94:271-273, 2004.

Iost N, Virág L, Hála O, Thormählen D, Papp JGy :Effects of the antifibrillatory compound tedisamil (KC-8857) on transmembrane currents in mammalian ventricular myocytes.
Current Medicinal Chemistry
11:3219-3228, 2004.

Biliczki P, Acsai K, Virág L, Tálosi L, Jost N, Biliczki A, Papp JGy, Varró A: Cellular electrophysiological effect of terikalant in the dog heart.
Eur.J.Pharmacol. 510:161-166, 2005.

Borbély A, Tóth A, Édes I, Vaszily M, Virág L, Szûts V, Papp JGy, Varró A, Paulus WJ, Van der Velden J, Stienen GJM, Papp Z: Peroxynitrite-induced alpha-actinin nitration and contractile alterations in isolated human myocardial cells.
Cardiovasc.Res.
67:225-233, 2005.

Jost N, Virág L, Bitay M, Takács J, Lengyel C, Biliczki P, Nagy Z, Bogáts G, Lathrop DA, Papp JGy, Varro A: Restricting excessive cardiac action potential and QT prolongation: a vital role for IKs in human ventricular muscle.
Circulation
112:1392-1399, 2005.

Márton Z, Pataricza J, Krassói I, Varró A, Papp JGy : NEP inhibitors enhance C-type natriuretic peptide-induced relaxation in porcine isolated coronary artery.
Vasc. Pharmacol. 43:207-12, 2005.

Ördög B, Brutyó E, Puskás LG, Papp JGy, Varró A, Szabad J, Boldogkõi Zs: Gene expression profiling of human cardiac potassium and sodium channels.
Int.J.Cardiol. 111:386-393, 2006.

Varró A, Papp JGy: Low penetrance, subclinical LQTS: concealed LQTS or silent LQTS?
Cardiovasc.Res. 70:404-406, 2006.

Pataricza J, Szolnoky J, Krassói I, Hegedüs Z, Kun A, Varró A, Papp JGy: Vasorelaxing effect of levosimendan against 5-hydroxy triptamine-induced contractions in isolated human conduit bypass grafts.
J.Pharm.Pharmacol. 58: 1107-1112, 2006.

Papp JGy, Pollesello P, Varró A, Végh Á: Effect of levosimendan and milrinone on regional myocardial ischemia- and reperfusion-induced arrhythmias in dogs.
J.Cardiovasc.Pharmacol.Therapeut. 11:129-135, 2006.

Papp JGy, Pollesello P, Varró A, Végh Á : The effect of levosimendan during long-term amiodarone-tratment in dogs.
Basic & Clinical Pharmacology and Toxicology 99:27-32, 2006.

Leprán I, Pollesello P, Vajda Sz, Varró A, Papp JGy: Preconditioning effects of levosimendan in a rabbit cardiac ischaemia-reperfusion model.
J.Cardiovasc.Pharmacol. 48:148-152, 2006.

Molnár A, Tóth A, Bagi Z, Papp Z, Édes I, Vaszily M, Galajda Z, Papp JGy, Varró A, Szüts V, Gerö D, Lazca Z, Szabó C : Activation of the Poly(ADP-Ribose) Polymerase Pathway in Human Heart Failure
Mol.Med. 12:143-152, 2006.

Farkas AS, Acsai K, Nagy N, Tóth A, Dési L, Orosz S, Forster T, Csanády M, Papp JGy, Varró A, Farkas A: Importance of extracardiac a1-adrenoceptor stimulation in assisting dofetilide to induce torsade de pointes in rabbit hearts.
Eur.J. Pharmacol. 537:118-125, 2006.

Jost N, Papp JGy, Varró A: Slow delayed rectifier potassium current (IKs) and the repolarization reserve.
Annals Noninvas. Electrocardiol. 12:64-78, 2007.

Lengyel Cs, Virág L, Bíró T, Jost N, Magyar J, Biliczki P, Kocsis E, Skoumal R, Nánási PP, Tóth M, Kecskeméti V, Papp JGy, Varró A: Diabetes mellitus attenuates the repolarization reserve in mammalian heart.
Cardiovasc.Res. 73:512-520, 2007.

Sas K, Csete K, Vezekényi Z, Sztricha L, Vécsei L, Papp JGy: Effect of citalopram and fluoxetine on the corticocerebral blood flow in conscious rabbits.
Acta Physiol. Hung. 94:167-177, 2007.

Lengyel Cs, Varró A, Tábori K, Papp JGy, Baczkó I: Combined pharmacologic block of IKr and IKs increases short-term QT interval variability and provokes torsades de pointes.
Br. J. Pharmacol. 151:941-951, 2007.

Acsai K, Kun A, Farkas AS, Fülöp F, Nagy N, Balázs M, Szentandrássy N, Nánási PP, Papp JGy, Varró A, Tóth A: Effect of partial blockade of the Na+/Ca2+-exchanger on Ca2+ handling in isolated rat ventricular myocytes.
Eur.J. Pharmacol. 576:1-6, 2007.

Tóth-Molnár E, Venglovecz V, Ózsvári B, Rakonczay Z, Varró A, Papp JGy, Tóth A, Lonovics I, Takáts T, Ignáth I, Iványi B, Hegyi P: A new experimental method to study the acid/base transporters and their regulation in lacrimal gland ductal epithelia.
Invest. Ophthal. & Visual Sci. 48:3746-3755, 2007.

Lengyel Cs, Virág L, Kovács PP, Kristóf A, Pacher P, Kocsis E, Koltai ZsM, Nánási PP, Tóth M, Kecskeméti V, Papp JGy, Varró A, Jost N: Role of slow delayed K+-current in QT prolongation in the alloxan-induced diabetic rabbit heart.
Acta Physiol. (Scand.) 192:359-368, 2008

Farkas AS, Acsai K, Nagy N, Tóth A, Fülöp F Seprényi G, Birinyi P, Nánási PP, Forster T, Csanády M, Papp JGy, Varró A, Farkas A : Na+/Ca2+ exchanger inhibition exerts positive inotropic effect in the rat heart, but fails to influence the contractility of the rabbit heart.
Br.J.Pharmacol. 154:93-104, 2008.

Birinyi P, Tóth A, Jóna I, Acsai K, Almássy J, Nagy N, Prorok J, Gherasim I, Papp Z, Hertelendy Z, Szentandrássy M, Bányász T, Fülöp F, Papp JGy, Varró A, Nánási PP, Magyar J: The Na+/Ca2+ exchange blocker SEA0400 fails to enhance cytosoloc Ca2+ transient and contractility in canine ventricular cardiomyocytes.
Cardiovasc. Res. 78:476-484, 2008.

Vincze D, Farkas AS, Rudas L, Makra P, Csik N, Leprán I, Forster T, Csanády M, Papp JGy, Varró A, Farkas A: Relevance of anaesthesia for dofetilide-induced torsades de pointes in a1-adrenoceptor-stimulated rabbits.
Br.J. Pharmacol. 153: 75-89, 2008.

Papp Gy, VarróA, Baczkó I: Genomics of cardiomyocyte signalling to treat and prevent heart failure ("EugeneHeart" Project).
Fókusz 3:29-30, 2008

Kun A, Király I, Pataricza J, Márton Z, Krassói I, Varró A, Simonsen U, Papp JGy, Pajor L : C-type natriuretic peptide hyperpolarizes and relaxes human penile resistance arteries.
J.Sex.Med. 5:1114-1125, 2008.

Pataricza J, Márton Z, Lengyel Cs, Tóth M, Papp JGy, Varró A, Kun A : Potassium channels sensitive to combination of charybdotoxin and apamin regulate the tone of diabetic isolated coronary arteries.
Acta Physiol. (Scand.) 194:35-43, 2008.

Koini EN, Papazafiri P, Vassilopoulos A, Koufaki M, Horváth Z, Koncz I, Virág L, Papp JGy, Varró A, Calogeropoulou T :  5,7,8-Trimethyl-benzopyran and 5,7,8-trimethyl-1,4-benzoxazine aminoamide derivatives as novel antiarrhythmics against ischemia-reperfusion injury.
J Med Chem. 52:2328-2340, 2009.

Farkas AS, Makra P, Csík N, Orosz Sz, Shattock MJ, Fülöp F, Forster T, Csanády M, Papp JGy, Varró A, Farkas A : The role of the Na(+)/Ca(2+) exchanger, I(Na) and I(CaLM) in the genesis of dofetilide-induced torsades de pointes in isolated, AV-blocked rabbit hearts.
Br.J. Pharmacol. 156:920-932, 2009.

Virág L, Acsai K, Hála O, Zaza A, Bitay M, Bogáts G, Papp JGy, Varró A: Self-augmentation of the lengthening of repolarization is related to the shape of the cardiac action potential: implications for reverse rate dependency.
Br.J. Pharmacol. 156:1076-1084, 2009.

Szolnoky J, Ambrus N, Szabó-Biczók A, Bogáts G, Papp JGy, Varró A, Pataricza J : Biseko colloidal solution diminishes the vasoreactivity of human isolated radial arteries. 
Eur J Cardiothorac Surg. 36:143-147, 2009.

Prorok J, Kovács PP, Kristóf A, Nagy N, Tombácz D, Tóth JS, Ördögh B, Jost N, Virág L, Papp JGy, Varró A, Tóth A, Boldogkői Zs: Herpes-virus mediated delivery of genetically encoded fluorescent Ca2+ sensor to canine cardiomyocytes.
Journal of Biomedicine and Biotechnology 2009:1-12, Paper 361795,2009. 

Nagy N, Szűts V, Horváth Z, Seprényi Gy, Farkas AS, Acsai K, Prorok J, Bitay M, Kun A, Pataricza J, Papp JGy, Nánási PP, Varró A, Tóth A: Does small conductance potassium channel contribute to cardiac repolarization?
Journal of Molecular and Cellular Cardiology 47:657-663, 2009.

Pataricza J, Krassói I, Ambrus N, Bitay M, Varró A, Papp JGy: Interspecies differences and extracellular calcium dependence in the vasorelaxing effect of cromakalim in isolated human, porcine and canine coronary arteries.
Journal of Cardiovascular Pharmacology and Therapeutics 15:289-295, 2010.

Farkas AS, Rudas L, Makra P, Csík N, Leprán I, Forster T, Csanády M. Papp JGy, Varró A, Farkas A: Biomarkers and endogenous determinants of dofetilide-induced torsades de pointes in alfa1-adrenoceptor-stimulated, anaesthetized rabbits.
British Journal of Pharmacology 161:1477-1495, 2010.

Virág L, Jost N, Papp R, Koncz I, Kristof A, Kohajda Zs, Harmati G, Carbonell-Pascual B, Ferrero JM(Jr), Papp JGy, Nánási PP, Varró A: Analysis of the contribution of  Ito to repolarization in canine ventricular myocardium.
British Journal of Pharmacology 164:93-105, 2011.

Koncz I, Szél T, Jaeger K, Baczkó I, Cerbai E, Romanelli MN, Papp JGy, Varró A: Selective pharmacological inhibition of the pacemaker channel isoforms (HCN1-4) as new possible therapeutic targets.
Current Medicinal Chemistry 18:3662-3674, 2011.

Szél T, Koncz I, Jost N, Baczkó I, Husti Z, Virág L, Bussek A, Wetter E, Ravens U, Papp JGy, Varró A: Class I/B antiarrhythmic property of rannolazine, a novel antianginal agent, in dog and human cardiac preparations.
European Journal of Pharmacology 662:31-39, 2011.

Lengyel Cs, Orosz A, Hegyi P, Komka Zs, Udvardy A, Bosnyák E, Trájer E, Pavlik G, Tóth M, Wittmann T, Papp JGy, Varró A, Baczkó I: Increased short-term variability of the QT interval in professional soccer players: possible implications for arrhythmia prediction.
Plos one 6:e18751, 2011.

Koncz I, Szél T, Bitay M, Cerbai E, Jaeger K. Fülöp F, Jost N, Virág L, Orvos P, Tálosi L, Kristóf A, Baczkó I, Papp JGy, Varró A: Electrophysiological effects of ivabradine in dog and human cardiac preparations: potential antiarrhythmic actions.
European Journal of Pharmacology 668:419-426, 2011.

Ambrus N, Szolnoky J, Pollesello P, Kun A, Varró A, Papp JGy, Pataricza J: Prolenged antispasmodic effect in isolated radial artery graft and pronunced platelet inhibition induced by the inodilator drug, levosimendan.
Basic & Clinical Pharmacology & Toxicology 110:269-274, 2012.

Kristóf A, Husti Z, Koncz I, Kohajda Zs, Szél T, Juhász V, Biliczki P, Jost N, Baczkó I, Papp JGy, Varró A, Virág L: Diclofenac Prolongs Repolarization in Ventricular Muscle with impaired Repolarization Reserve.
Plose one 7:e53255, 2012.

Szüts V, Ménesi D, Varga-Orvos Z, Zvara Á, Houshmand N, Bitay M, Bogáts G, Virág L, Baczkó I, Szalontai B, Geramipoor A, Cotella D, Wettwer E, Ravens U, Deák F, Puskás LG, Papp JGy, Kiss I, Varró A, Jost N: Altered expression of genes for Kir ion channels in dilated cardiomyopathy.
Can. J. Physiol. Pharm. 91:648-656, 2013.

Király I, Pataricza J, Bajory Z, Simonsen U, Varró A, Papp JGy, Pajor L, Kun A: Involvement of large conductance Ca2+-activated K+ channels in both nitric oxide and endothelium derived hyperpolarization-type relaxation in human penile small arteries.
Basic & Clin. Pharm & Toxicol. 113:19-24, 2013.

Pataricza J, Ambrus N, Pollesello P, Levijoki J, Kun A, Varró A, Papp JGy: Inhibition of thrombin-induced platelet aggregation by levosimendan is modified by small changes in albumin concentration in vitro.
Experimental and Clinical Cardiology (accepted for publication) 2013.

Nagy N, Acsai K, Kormos A, Sebők Zs, Farkas AS, Jost N, Nánási PP, Papp JGy, Varró A, Tóth A: Ca2+ -induced augmentation of the inward rectifier potassium current (IK1) in canine and human ventricular myocardium.
Pflügers Archiv - European Journal of Pharmacology 465: 1621-1635, 2013.

Jost N, Nagy N, Corici C, Kohajda Zs, Horváth A, Acsai K, Biliczki P, Levijoki J, Pollesello P, Koskelainen T, Otsomaa L, Tóth A, Papp JGy, Varró A, Virág L: ORM-10103, a novel specific inhibitor of the sodium/calcium exchanger, decreases early and delayed afterdepolarization in the canine heart.
British Journal of Pharmacology 170: 768-778, 2013.

Jost N, Virág L, Comtois P, Ördög B, Szűts V, Seprényi Gy, Bitay M, Kohajda Zs, Koncz I, Nagy N, Szél T, Magyar J, Kovács M, Puskás LG, Lengyel Cs, Wettwer E, Ravens U, Nánási PP, Papp JGy, Varró A, Nattel S: Ionic mechanisms limiting cardiac repolarization-reserve in humans compared to dogs.
J. Physiol. (London) 591: 4189-4206, 2013.

Acsai K, Oravecz K, Kormos A, Márton Z, Papp JGy, Varró A: Shift in Na+/Ca2+ exchange balance modulates the inotropic consequences of the NCX inhibition
Acta Physiologica 211: (697) 93-94, 2014.

Kormos A, Nagy N, Acsai K, Vaczi K, Agoston S, Pollesello P, Levijoki J, Szentandrassy N, Papp JGy, Varró A, Tóth A: Efficacy of selective NCX inhibition by ORM-10103 during simulated ischaemia/reperfusion.
European Journal of Pharmacology 740: 539-551, 2014.

Kun A, Seprényi Gy, Varró A, Papp JGy, Pataricza J: Neurogenic Contraction Induced by the Antiarrhythmic Compound, AVE 0118, in Rat Small Mesenteric Arteries.
Basic & Clinical Pharmacology & Toxicology 115: 315-320, 2014.

Nagy N, Kormos A, Kohajda Z, Szebeni A, Szepesi J, Pollesello P, Levijoki J, Acsai K, Virág L, Nánási PP, Papp JGy, Varró A, Tóth A: Selective Na/Ca exchanger inhibition prevents Ca overload induced triggered arrhythmias.
British Journal of Pharmacology 171: (24) 5665-5681, 2014.

Orosz S, Sarusi A, Csík N, Papp JGy, Varró A, Farkas S, Forster T, Farkas AS, Farkas A: The assessment of efficacy of proarrhytmia biomarkers in isolated rabbit hearts with attenuated repolarization reserve.
Journal of Cardiovascular Pharmacology 64: (3) 266-276, 2014.

Pataricza J, Ambrus N, Pollesello P, Levijoki J, Kun A, Varró A, Papp JGy : Inhibition of thrombin-induced platelet aggregation by levosimendan is modified by small changes in albumin concentration in vitro.
Experimental and Clinical Cardiology (2014)

Sarusi A, Rárosi F, Szűcs M, Csík N, Farkas AS, Papp JGy, Varró A, Forster T, Curtis MJ, Farkas A : Absolute beat-to-beat variability and instability parameters of ECG intervals: biomarkers for predicting ischaemia-induced ventricular fibrillation.
British Journal of Pharmacology 171: 1772-1782, 2014.

Orosz A, Csajbok E, Czekus C, Gavaller H, Magony S, Valkusz Z, Varkonyi TT, Nemes A, Baczko I, Forster T, Wittmann T, Papp JGy, Varro A, Lengyel C: Increased Short-Term Beat-To-Beat Variability of QT Interval in Patiens with Acromegaly.
Plose one 10:(4) p. e0125639, 2015.

Szepesi J, Acsai K, Sebok Z, Prorok J, Pollesello P, Levijoki J, Papp JGy, Varro A, Toth A : Comparison of the efficiency of Na+/Ca2+ exchanger or Na+/H+ exchanger inhibition and their combination in reducing coronary reperfusion-induced arrhythmias.
Journal of Physiology and Pharmacology 66:(2) pp. 215-226, 2015

Kui P, Orosz S, Takács H, Sarusi A, Csík N, Rárosi F, Csekő C, Varró A, Papp JGy, Forster T, Farkas AS, Farkas A: New in vitro model for proarrhythmia safety screening: IKs inhibition potentiates the QTc prolonging effect of IKr inhibitors in isolated guinea pig hearts.
J Pharmacol Toxicol Methods 80:26-34, 2016.

Nagy L, Pollesello P, Haikala H, Végh Á, Sorsa T, Levijoki J, Szilágyi S, Édes I, Tóth A, Papp Z, Papp JGy: ORM-3819 promotes cardiac contractility through Ca(2+) sensitization in combination with selective PDE III inhibition, a novel approach to inotropy.
Eur J Pharmacol 775:120-9, 2016.

Pollesello P, Papp Z, Papp JGy: Calcium sensitizers: What have we learned over the last 25 years?
Int J Cardiol. 203:543-8, 2016.

Takács H, Kui P, Farkas AS, Sarusi A, Forster T, Papp JGy, Varró A, Curtis MJ, Shattock MJ, Farkas A: Ventricular cycle length irregularity affects the correlation between ventricular rate and coronary flow in isolated, Langendorff perfused guinea pig hearts.
J Pharmacol Toxicol Methods. 77:45-52, 2016.

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