Name: János Prorok, MSc, PhD          research fellow Addresses: Information Telephone: 36-62-542-653 Telefax: 36-62-545-680 E-mail: prorok.janos@med.u-szeged.hu

Educational background:
2014, PhD degree (“summa cum laude”), (Studies on the role of disturbed Ca2+ homeostasis in the pathomechanism of the cardiac effects of experimental diabetes using conventional and novel experimental techniques) University of Szeged, Hungary
2004, Biology degree, University of Szeged, Hungary

Teaching experience:
Pharmacology practice from 2015 up to present to undergraduate medical students
Electrophysiology (lectures and seminars) from 2014 up to present to undergraduate students
Tutor in Students' Scholarly Circle
Thesis Supervisor

Research interest:
Electrophysiology and pharmacology of the heart, cellular Ca2+ homeostasis, role of NCX in arrhythmia and other pathophysiological heart models, drug research.

Experimental methods:
intracellular fluorescence measurements, microscopy, action potential mapping, isolated heart (Langendorff) experiments, cell isolation, cell culture, cell shortening measurement, sharp electrode technique

Awards
Travel Grant for EWGCCE, 2009, Madrid, Spain

Language
- English intermediate
- Italian basic

Membership:
- Hungarian Experimental and Clinical Pharmacological Society (2016)
- Hungarian Physiological Society (2008)
- Hungarian Cardiological Society (2007)
- European Working Group on Cardiac Cellular Electrophysiology (2009)

Publication records:
9 full length papers
Citation: 128
Hirsch index: 6

Selected publications
Kohajda Z, Farkas-Morvay N, Jost N, Nagy N, Geramipour A, Horváth A, Varga RS, Hornyik T, Corici C, Acsai K, Horváth B, Prorok J, Ördög B, Déri S, Tóth D, Levijoki J, Pollesello P, Koskelainen T, Otsomaa L, Tóth A, Baczkó I, Leprán I, Nánási PP, Papp JG, Varró A, Virág L. The Effect of a Novel Highly Selective Inhibitor of the Sodium/Calcium Exchanger (NCX) on Cardiac Arrhythmias in In Vitro and In Vivo Experiments.
PLoS One. 2016 Nov 10;11(11):e0166041. doi: 10.1371/journal.pone.0166041.

Geramipour A, Kohajda Z, Corici C, Prorok J, Szakonyi Z, Oravecz K, Marton Z, Nagy N, Toth A, Acsai K, Virag L, Varro A, Jost N, The investigation of the cellular electrophysiological and antiarrhythmic effects of a novel selective sodium-calcium exchanger inhibitor, GYKB-6635, in canine and guinea-pig hearts.
CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY 2016: pp. 1-12. (2016)

Major P, Baczko I, Hiripi L, Odening KE, Juhasz V, Kohajda Z, Horvath A, Seprenyi G, Kovacs M, Virag L, Jost N, Prorok J, Ordog B, Doleschall Z, Nattel S, Varro A, Bosze Z A novel transgenic rabbit model with reduced repolarization reserve: long QT syndrome caused by a dominant-negative mutation of KCNE1 gene.
BRITISH JOURNAL OF PHARMACOLOGY 173:(12) pp. 2046-2061. (2016)

Szepesi J, Acsai K, Sebok Z, Prorok J, Pollesello P, Levijoki J, Papp JG, Varro A, Toth A Comparison of the efficiency of Na+/Ca2+ exchanger or Na+/H+ exchanger inhibition and their combination in reducing coronary reperfusion-induced arrhythmias.
JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY 66:(2) pp. 215-226. (2015)

Ujhelly O, Szabo V, Kovacs G, Vajda F, Mallok S, Prorok J, Acsai K, Hegedus Z, Krebs S, Dinnyes A, Pirity MK Lack of Rybp in Mouse Embryonic Stem Cells Impairs Cardiac Differentiation.
STEM CELLS AND DEVELOPMENT 24:(18) pp. 2193-2205. (2015)

Prorok J, Kovács PP, Kristóf AA, Nagy N, Tombácz D, Tóth JS, Ordög B, Jost N, Virág L, Papp JG, Varró A, Tóth A, Boldogkoi Z. Herpesvirus-mediated delivery of a genetically encoded fluorescent Ca2+ sensor to canine cardiomyocytes.
J Biomed Biotechnol. 2009;2009:361795.

Nagy N, Szuts V, Horváth Z, Seprényi G, Farkas AS, Acsai K, Prorok J, Bitay M, Kun A, Pataricza J, Papp JG, Nánási PP, Varró A, Tóth A. Does small-conductance calcium-activated potassium channel contribute to cardiac repolarization?
J Mol Cell Cardiol. 2009 Nov;47(5):656-63. Epub 2009 Jul 24.

Birinyi P, Tóth A, Jóna I, Acsai K, Almássy J, Nagy N, Prorok J, Gherasim I, Papp Z, Hertelendi Z, Szentandrássy N, Bányász T, Fülöp F, Papp JG, Varró A, Nánási PP, Magyar J. The Na+/Ca2+ exchange blocker SEA0400 fails to enhance cytosolic Ca2+ transient and contractility in canine ventricular cardiomyocytes.
Cardiovasc Res. 2008 Jun 1;78(3):476-84.

Pecze L, Szabó K, Széll M, Jósvay K, Kaszás K, Kúsz E, Letoha T, Prorok J, Koncz I, Tóth A, Kemény L, Vizler C, Oláh Z. Human keratinocytes are vanilloid resistant.
PLoS One. 2008;3(10):e3419. Epub 2008 Oct 14.