Dr. István Leprán Name: István Leprán PhD., D.Sc.

Addresses: Information
Telephone: 36-62-545-676
Telefax: 36-62-544-565

E-mail: lepran.istvan@med.u-szeged.hu


Date of birth: 10 June 1953, Szeged, Hungary

Marital status: married, 2 children

Educational background:
-1971-76  Albert Szent-Györgyi Medical University, Faculty of Pharmacy
-1987  Ph.D. degree (Candidate of Sciences)
-1998  Habilitation in Medicine (Med. Habil.)
-1999  Clinical Pharmacy Specialist
-2002  Doctor of Sciences (D.Sc.)

-1976-86 Research associate
-1986-95 Assistant professor
-1995-2004 Associate professor
-1996-   Head of Laboratory of Cardiac Arrhythmias
-2004-   Professor

Teaching experience:
-1982- Lecturer in Pharmacology
-1989- Cardiovascular pharmacology - Ph.D. program

-1997-2000 Széchenyi Professorship
-1997-1998    Best Lecturer of the Year (Hungarian class)
-1999-2000    Best Lecturer of the Year (Hungarian class)
-1999-2000    Best Lecturer of the Year (English class)
-2000-2001    Best Lecturer of the Year (Hungarian class)
-2001-2002    Best Lecturer of the Year (Hungarian class)
-2002-2003    Best Lecturer of the Year (Hungarian class)
-2002-2004    Istvan Széchenyi Professorship
-2004-2005      Best Lecturer of the Year (English class)
-2005-2006      Best Lecturer of the Year (Hungarian class)
-2006-2007      Best Lecturer of the Year (Hungarian class)
-2006-2007      József Öveges Professorship
-2007                Distinguished Lecturer of the Medical Faculty
-2007-2008      Best Lecturer of the Year (English class)
-2007-2008      Best Lecturer of the Year (Hungarian class)
-2008-2009      Best Lecturer of the Year (English class)
-2008-2009      Best Lecturer of the Year (Hungarian class)

-1981 Ernst Moritz Arndt Universitat, Dept. Pharmacology, Greifsvald, Germany
-1983-84 Thomas Jefferson University, Dept. Physiology, Philadelphia, PA, USA
-1993 Rijksuniversiteit Gent, Dept. Pharmacology, Gent, Belgium

- Hungarian Experimental and Clinical Pharmacological Society
- Hungarian Physiological Society
- Hungarian Cardiological Society
- Hungarian Society for Pharmaceutical Sciences
- International Society for Heart Research

Research interest:
Pathophysiology and pharmacology of myocardial infarction, including:
- prevention of life threatening arrhythmias by polyunsaturated fatty acid rich diet;
- antiischemic effects of K-channel modulators;
- investigation of the proarrhythmic potential of drugs.
- similarities in acute myocardial infarction and acute inflammatory reaction;
- protein synthesis inhibitors during experimental myocardial infarction;

Selected publications:

Csányi G, Kis B, Gecse A, Telegdy G, Szupera Z, Vécsei L, Szente M, Leprán I, Mezei Z: Effects of 3-aminopyridine-induced seizures on platelet eicosanoid synthesis.
Pharmacol Rep. 60: 345-352. 2008.

Vincze D, Farkas AS, Rudas L, Makra P, Csík N, Leprán I, Forster T, Csanády M, Papp JG, Varró A, Farkas A: Relevance of anaesthesia for dofetilide-induced torsades de pointes in alpha1-adrenoceptor-stimulated rabbits.
Br J Pharmacol.153: 75-89. 2008.

Vajda S, Baczkó I, Leprán I: Selective cardiac plasma-membrane KATP channel inhibition is defibrillatory and improves survival during acute myocardial ischemia and reperfusion.
European J. Pharmacol. 577: 115-123. 2007.

Csanyi G, Lepran I, Flesch T, Telegdy G, Szabo G, Mezei Z: Lack of endothelium-derived hyperpolarizing factor (EDHF) up-regulation in endothelial dysfunction in aorta in diabetic rats.
Pharmacol Rep.59: 447-55. 2007.

Leprán I, Pollesello P, Vajda S, Varró A, Papp JGy: Preconditioning effects of levosimendan in a rabbit cardiac ischemia-reperfusion model.
Pharmacol. 48: 148-152. 2006.

Földes G, Vajda S, Lakó-Futó Z, Sármán B, Skoumal R, Ilves M, deChâtel R, Karádi I, Tóth M, Ruskoaho H, Leprán I: Distinct modulation of angiotensin II-induced early left ventricular hypertrophic gene programming by dietary fat type.
J. Lipid Res. 47: 1219-1226. 2006.

Leprán I, Papp JGy: Effect of long-term oral pretreatment with levosimendan on cardiac arrhythmias during coronary artery occlusion in conscious rats.
European J. Pharmacol. 464: 171-176. 2003.

Farkas A, Leprán I, Papp JGy: Proarrhythmic effects of intravenous quinidine, amiodarone, D-sotalol, and almokalant in the anesthetized rabbit model of torsade de pointes.
J. Cardiovasc. Pharmacol. 39: 287-297. 2002.

Pálfi A, Simonka JA, Pataricza M, Tekulics P, Leprán I, Papp JGy, Gulya K: Postischemic calmodulin gene expression in the rat hippocampus.
Life Sci. 68: 2373-2381. 2001.

Baczkó I, El-Reyani NE, Farkas A, Virág L, Iost N, Leprán I, Mátyus P, Varró A, Papp JG: Antiarrhythmic and electrophysiological effects of GYKI-16638, a novel  N-(phenoxyalkyl)-N-phenylalkylamine, in rabbits.
European J. Pharmacol. 404: 181-190. 2000.  

El-Reyani NE, Bozdogan Ö, Baczkó I, Leprán I, Papp JGy: Comparison of glibenclamide and glimepiride in reperfusion-induced arrhythmias in rats.
European J. Pharmacol. 365: 187-192. 1999. 

Farkas A, Leprán I, Papp JGy: Comparison of the antiarrhythmic and proarrhythmic effect of almokalant in anaesthetised rabbits.
European J. Pharmacol. 346: 245-253. 1998.

Baczkó I, Leprán I, Papp JGy: Influence of anaesthetics on sudden death and the incidence and duration of reperfusion-induced arrhythmias in rats.
J. Cardiovasc. Pharmacol. 29: 196-201. 1997.

Baczkó I, Leprán I, Papp JGy: KATP channel modulators increase survival rate during coronary occlusion-reperfusion in anaesthetized rats.
European J. Pharmacol. 324: 77-83. 1997.

Leprán I., Baczkó I., Varró A., Papp J.Gy.: ATP-sensitive potassium channel modulators: Both pinacidil and glibenclamide produce antiarrhythmic activity during acute myocardial infarction in conscious rats.
J. Pharmacol. Exp. Ther. 277: 1215-1220. 1996.

Leprán I, Papp JGy: Effect of moxonidine on arrhythmias induced by coronary artery occlusion and reperfusion.
J. Cardiovasc. Pharmacol. 24 (Suppl. I): S9-S15. 1994.

Leprán I, Szekeres L: Effect of dietary sunflower seed oil on the severity of reperfusion induced arrhythmias in anes­thetized rats.
J. Cardiovasc. Pharmacol. 19: 40-44. 1992.

Leprán I, Lefer AM: Protective actions of propyl gallate, a lipoxygenase inhibitor, on the ischemic myocardium.
Circ. Shock 15: 79-88. 1985.

Leprán I, Parratt JR, Szekeres L, Wainwright CL: The effects of metoprolol and dazmegrel, alone and in combination, on arrhythmias, induced by coronary artery occlusion in conscious rats.
Br. J. Pharmac. 86: 229-234. 1985.

Leprán I, Koltai M, Siegmund W, Szekeres L: Coronary artery ligation, early arrhythmias, and determination of the ischemic area in conscious rats.
J. Pharmacol. Meth. 9: 219-230. 1983.

Leprán I, Koltai M, Szekeres L: Effect of non-steroid anti-inflammatory drugs in experimental myocardial infarction in rats.
European J. Pharmacol. 69: 235-238. 1981.

Leprán I, Nemecz Gy, Koltai M, Szekeres L: Effect of linoleic acid-rich diet on the acute phase of coronary occlusion in conscious rats: Influence of indomethacin and aspirin.
J. Cardiovasc. Pharmacol. 3: 847-853. 1981