Szegedi Tudományegyetem Szent-Györgyi Albert Orvostudományi Kar

Farmakológiai és Farmakoterápiai Intézet

Legfrissebb publikációk

Cardiac transmembrane ion channels and action potentials: cellular physiology and arrhythmogenic behavior

Varró A, Tomek J, Nagy N, Virág L, Passini E, Rodriguez B, Baczkó I.

Physiol Rev. 2021 Jul 1;101(3):1083-1176. doi: 10.1152/physrev.00024.2019.

PMID: 33118864




Arrhythmogenic Remodeling in the Failing Heart

Husti Z, Varró A, Baczkó I.

Cells. 2021 Nov 17;10(11):3203. doi: 10.3390/cells10113203.

PMID: 34831426


Sex-specific effects of metformin and liraglutide on renal pathology and expression of connexin 45 and pannexin 1 following long-term high-fat high-sugar diet

Luetić M, Kretzschmar G, Grobe M, Jerčić L, Bota I, Ivić V, Balog M, Zjalić M, Vitlov Uljević M, Heffer M, Gaspar R, Tabi T, Vukojević K, Vari SG, Filipović N.

Acta Histochem. 2021 Dec;123(8):151817. doi: 10.1016/j.acthis.2021.151817. Epub 2021 Nov 19.

PMID: 34808525


Inhibition of NHE-1 Increases Smoke-Induced Proliferative Activity of Barrett’s Esophageal Cell Line

Becskeházi E, Korsós MM, Gál E, Tiszlavicz L, Hoyk Z, Deli MA, Köhler ZM, Keller-Pintér A, Horváth A, Csekő K, Helyes Z, Hegyi P, Venglovecz V.

Int J Mol Sci. 2021 Sep 30;22(19):10581. doi: 10.3390/ijms221910581.

PMID: 34638919


Docosahexaenoic acid normalizes QT interval in long QT type 2 transgenic rabbit models in a genotype-specific fashion

Castiglione A, Hornyik T, Wülfers EM, Giammarino L, Edler I, Jowais JJ, Rieder M, Perez-Feliz S, Koren G, Bősze Z, Varró A, Zehender M, Brunner M, Bode C, Liin SI, Larsson HP, Baczkó I, Odening KE.

Europace. 2022 Mar 2;24(3):511-522. doi: 10.1093/europace/euab228.

PMID: 34601592


Mislocalization of CFTR expression in acute pancreatitis and the beneficial effect of VX-661 + VX-770 treatment on disease severity

Fűr G, Bálint ER, Orján EM, Balla Z, Kormányos ES, Czira B, Szűcs A, Kovács DP, Pallagi P, Maléth J, Venglovecz V, Hegyi P, Kiss L, Rakonczay Z Jr.

J Physiol. 2021 Nov;599(22):4955-4971. doi: 10.1113/JP281765. Epub 2021 Oct 21.

PMID: 34587656


New Strategies for the Treatment of Atrial Fibrillation

Jost N, Christ T, Magyar J.

Pharmaceuticals (Basel). 2021 Sep 15;14(9):926. doi: 10.3390/ph14090926.

PMID: 34577626


The Effect of Citral on Aquaporin 5 and Trpv4 Expressions and Uterine Contraction in Rat-An Alternative Mechanism

Seres-Bokor A, Kemény KK, Taherigorji H, Schaffer A, Kothencz A, Gáspár R, Ducza E.

Life (Basel). 2021 Aug 30;11(9):897. doi: 10.3390/life11090897.

PMID: 34575046


Non-invasive smooth muscle electromyography (SMEMG) as a novel monitoring technology of the gastrointestinal tract of awake, free-moving pigs-A pilot study

Nagy K, Fébel H, Bazar G, Grosz G, Gáspár R, Ferenc Szűcs K, Tóth T.

PLoS One. 2021 Sep 13;16(9):e0257311. doi: 10.1371/journal.pone.0257311. eCollection 2021.

PMID: 34516588


Peripheral and Autonomic Neuropathy Status of Young Patients With Type 1 Diabetes Mellitus at the Time of Transition From Pediatric Care to Adult-Oriented Diabetes Care

Vágvölgyi A, Maróti Á, Szűcs M, Póczik C, Urbán-Pap D, Baczkó I, Nemes A, Csajbók É, Sepp K, Kempler P, Orosz A, Várkonyi T, Lengyel C.

Front Endocrinol (Lausanne). 2021 Aug 27;12:719953. doi: 10.3389/fendo.2021.719953. eCollection 2021.

PMID: 34512550


Phenotypic plasticity of melanocytes derived from human adult skin

Vidács DL, Veréb Z, Bozó R, Flink LB, Polyánka H, Németh IB, Póliska S, Papp BT, Manczinger M, Gáspár R, Mirdamadi S, Kemény L, Bata-Csörgő Z.

Pigment Cell Melanoma Res. 2022 Jan;35(1):38-51. doi: 10.1111/pcmr.13012. Epub 2021 Aug 31.

PMID: 34467641


Canine Myocytes Represent a Good Model for Human Ventricular Cells Regarding Their Electrophysiological Properties

Nánási PP, Horváth B, Tar F, Almássy J, Szentandrássy N, Jost N, Baczkó I, Bányász T, Varró A.

Pharmaceuticals (Basel). 2021 Jul 29;14(8):748. doi: 10.3390/ph14080748.

PMID: 34451845


The development of L-type Ca2+ current mediated alternans does not depend on the restitution slope in canine ventricular myocardium

Tóth N, Szlovák J, Kohajda Z, Bitay G, Veress R, Horváth B, Papp JG, Varró A, Nagy N.

Sci Rep. 2021 Aug 17;11(1):16652. doi: 10.1038/s41598-021-95299-7.

PMID: 34404848


Sex differences in oxidative stress level and antioxidative enzymes expression and activity in obese pre-diabetic elderly rats treated with metformin or liraglutide

Matić A, Vuković R, Heffer M, Balog M, Ivić V, Gaspar R, Ducza E, Szucs KF, Seres A, Vari SG, Drenjančević I.

Croat Med J. 2021 Jun 30;62(3):215-226. doi: 10.3325/cmj.2021.62.215.

PMID: 34212558


High-throughput rat immunoglobulin G N-glycosylation profiling revealed subclass-specific changes associated with chronic stress

Habazin S, Mlinarević D, Balog M, Bardak A, Gaspar R, Szűcs KF, Vari SG, Vučković F, Lauc G, Novokmet M, Heffer M.

J Proteomics. 2021 Aug 15;245:104293. doi: 10.1016/j.jprot.2021.104293. Epub 2021 Jun 10.

PMID: 34118474


Disarranged neuroplastin environment upon aging and chronic stress recovery in female Sprague Dawley rats

Balog M, Blažetić S, Ivić V, Labak I, Krajnik B, Marin R, Canerina-Amaro A, de Pablo DP, Bardak A, Gaspar R, Szűcs KF, Vari SG, Heffer M.

Eur J Neurosci. 2022 May;55(9-10):2474-2490. doi: 10.1111/ejn.15256. Epub 2021 May 14.

PMID: 33909305


Detection of acute stress by smooth muscle electromyography: A translational study on rat and human

Pribék IK, Szűcs KF, Süle M, Grosz G, Ducza E, Vigh D, Tóth E, Janka Z, Kálmán J, Datki ZL, Gáspár R, Andó B.

Life Sci. 2021 Jul 15;277:119492. doi: 10.1016/j.lfs.2021.119492. Epub 2021 Apr 14.

PMID: 33864819


Small Conductance Ca2+ -Activated K+ (SK) Channel mRNA Expression in Human Atrial and Ventricular Tissue: Comparison Between Donor, Atrial Fibrillation and Heart Failure Tissue

Darkow E, Nguyen TT, Stolina M, Kari FA, Schmidt C, Wiedmann F, Baczkó I, Kohl P, Rajamani S, Ravens U, Peyronnet R.

Front Physiol. 2021 Apr 1;12:650964. doi: 10.3389/fphys.2021.650964. eCollection 2021.

PMID: 33868017


Transgenic rabbit models for cardiac disease research

Hornyik T, Rieder M, Castiglione A, Major P, Baczko I, Brunner M, Koren G, Odening KE.

Br J Pharmacol. 2022 Mar;179(5):938-957. doi: 10.1111/bph.15484. Epub 2021 May 10.

PMID: 33822374


Correlations between left ventricular rotational mechanics and parasympathetic autonomic function—results from the three-dimensional speckle-tracking echocardiographic MAGYAR-Healthy Study

Nemes A, Kalapos A, Domsik P, Orosz A, Lengyel C.

Quant Imaging Med Surg. 2021 Apr;11(4):1613-1618. doi: 10.21037/qims-20-544.

PMID: 33816195


Pancreatitis severity in mice with impaired CFTR function but pancreatic sufficiency is mediated via ductal and inflammatory cells-Not acinar cells

Trapp S, Aghdassi AA, Glaubitz J, Sendler M, Weiss FU, Kühn JP, Kromrey ML, Mahajan UM, Pallagi P, Rakonczay Z Jr, Venglovecz V, Lerch MM, Hegyi P, Mayerle J.

J Cell Mol Med. 2021 May;25(10):4658-4670. doi: 10.1111/jcmm.16404. Epub 2021 Mar 8.

PMID: 33682322


Mapping genetic changes in the cAMP-signaling cascade in human atria

Garnier A, Bork NI, Jacquet E, Zipfel S, Muñoz-Guijosa C, Baczkó I, Reichenspurner H, Donzeau-Gouge P, Maier LS, Dobrev D, Girdauskas E, Nikolaev VO, Fischmeister R, Molina CE.

J Mol Cell Cardiol. 2021 Jun;155:10-20. doi: 10.1016/j.yjmcc.2021.02.006. Epub 2021 Feb 22.

PMID: 33631188


Knowledge, Attitude, and Practices (KAPs) of Community Pharmacists Regarding COVID-19: A Cross-Sectional Survey in 2 Provinces of Pakistan

Muhammad K, Saqlain M, Muhammad G, Hamdard A, Naveed M, Butt MH, Khan S, Ismael NS, Khan Z, Karatas Y.

Disaster Med Public Health Prep. 2021 Feb 16:1-9. doi: 10.1017/dmp.2021.54. Online ahead of print.

PMID: 33588970


Attenuation of nociceptive and paclitaxel-induced neuropathic pain by targeting inflammatory, CGRP and substance P signaling using 3-Hydroxyflavone

Ullah R, Ali G, Subhan F, Naveed M, Khan A, Khan J, Halim SA, Ahmad N, Zakiullah, Al-Harrasi A.

Neurochem Int. 2021 Mar;144:104981. doi: 10.1016/j.neuint.2021.104981. Epub 2021 Feb 5.

PMID: 33549629


The ontogeny of kisspeptin receptor in the uterine contractions in rats: Its possible role in the quiescence of non-pregnant and pregnant uteri

Schaffer A, Hajagos-Tóth J, Ducza E, Bódi N, Bagyánszki M, Szalai Z, Gáspár R.

Eur J Pharmacol. 2021 Apr 5;896:173924. doi: 10.1016/j.ejphar.2021.173924. Epub 2021 Feb 3.

PMID: 33548216


Polysaccharides; Classification, Chemical Properties, and Future Perspective Applications in Fields of Pharmacology and Biological Medicine (A Review of Current Applications and Upcoming Potentialities)

Mohammed ASA, Naveed M, Jost N.

J Polym Environ. 2021;29(8):2359-2371. doi: 10.1007/s10924-021-02052-2. Epub 2021 Jan 27.

PMID: 33526994


Increased expression of dendrin in the dorsal horn of the spinal cord during stress is regulated by sex hormones

Jurić M, Balog M, Ivić V, Bošković M, Benzon B, Racetin A, Vukojević K, Bočina I, Kević N, Restović I, Szűcs KF, Gáspár R, Heffer M, Vari SG, Filipović N.

Neuropeptides. 2021 Apr;86:102126. doi: 10.1016/j.npep.2021.102126. Epub 2021 Jan 23.

PMID: 33524899


Evidence for diagnosis of early chronic pancreatitis after three episodes of acute pancreatitis: a cross-sectional multicentre international study with experimental animal model

Hegyi PJ, Soós A, Tóth E, Ébert A, Venglovecz V, Márta K, Mátrai P, Mikó A, Bajor J, Sarlós P, Vincze Á, Halász A, Izbéki F, Szepes Z, Czakó L, Kovács G, Papp M, Dubravcsik Z, Varga M, Hamvas J, Németh BC, Macarie M, Ince AT, Bordin DS, Dubtsova EA, Kiryukova MA, Khatkov IE, Bideeva T, Mickevicius A, Ramírez-Maldonado E, Sallinen V, Erőss B, Pécsi D, Szentesi A, Párniczky A, Tiszlavicz L, Hegyi P.

Sci Rep. 2021 Jan 14;11(1):1367. doi: 10.1038/s41598-020-80532-6.

PMID: 33446814


Kv1.1 potassium channel subunit deficiency alters ventricular arrhythmia susceptibility, contractility, and repolarization

Trosclair K, Si M, Watts M, Gautier NM, Voigt N, Traylor J, Bitay M, Baczko I, Dobrev D, Hamilton KA, Bhuiyan MS, Dominic P, Glasscock E.

Physiol Rep. 2021 Jan;9(1):e14702. doi: 10.14814/phy2.14702.

PMID: 33427415


Matrix Metalloproteinases Repress Hypertrophic Growth in Cardiac Myocytes

Euler G, Locquet F, Kociszewska J, Osygus Y, Heger J, Schreckenberg R, Schlüter KD, Kenyeres É, Szabados T, Bencsik P, Ferdinandy P, Schulz R.

Cardiovasc Drugs Ther. 2021 Apr;35(2):353-365. doi: 10.1007/s10557-020-07138-y. Epub 2021 Jan 5.

PMID: 33400052


Blockade of sodium‑calcium exchanger via ORM-10962 attenuates cardiac alternans

Szlovák J, Tomek J, Zhou X, Tóth N, Veress R, Horváth B, Szentandrássy N, Levijoki J, Papp JG, Herring N, Varró A, Eisner DA, Rodriguez B, Nagy N.

J Mol Cell Cardiol. 2020 Dec 28:S0022-2828(20)30355-2. doi: 10.1016/j.yjmcc.2020.12.015.

PMID: 33383036


Muscarinic agonists inhibit the ATP-dependent potassium current and suppress the ventricle-Purkinje action potential dispersion

Magyar T, Árpádffy-Lovas T, Pászti B, Tóth N, Szlovák J, Gazdag P, Kohajda Z, Gyökeres A, Györe B, Gurabi Z, Jost N, Virág L, Papp JG, Nagy N, Koncz I.

Can J Physiol Pharmacol. 2021 Feb;99(2):247-253. doi: 10.1139/cjpp-2020-0408. Epub 2020 Nov 26.

PMID: 33242286


Antiarrhythmic and cardiac electrophysiological effects of SZV-270, a novel compound with combined Class I/B and Class III effects, in rabbits and dogs

Varga RS, Hornyik T, Husti Z, Kohajda Z, Krajsovszky G, Nagy N, Jost N, Virág L, Tálosi L, Mátyus P, Varró A, Baczkó I.

Can J Physiol Pharmacol. 2021 Jan;99(1):89-101. doi: 10.1139/cjpp-2020-0412. Epub 2020 Sep 24.

PMID: 32970956


Cardiac electrophysiological effects of ibuprofen in dog and rabbit ventricular preparations: possible implication to enhanced proarrhythmic risk

Pászti B, Prorok J, Magyar T, Árpádffy-Lovas T, Györe B, Topál L, Gazdag P, Szlovák J, Naveed M, Jost N, Nagy N, Varró A, Virág L, Koncz I.

Can J Physiol Pharmacol. 2021 Jan;99(1):102-109. doi: 10.1139/cjpp-2020-0386. Epub 2020 Sep 16.

PMID: 32937079


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