Szegedi Tudományegyetem

Farmakológiai és Farmakoterápiai Intézet

Legfrissebb publikációk

Antiarrhythmic and cardiac electrophysiological effects of SZV-270, a novel compound with combined Class I/B and Class III effects, in rabbits and dogs

Varga RS, Hornyik T, Husti Z, Kohajda Z, Krajsovszky G, Nagy N, Jost N, Virág L, Tálosi L, Mátyus P, Varró A, Baczkó I.

Can J Physiol Pharmacol. 2020 Sep 24. doi: 10.1139/cjpp-2020-0412.

PMID: 32970956


Discovery and characterization of ORM-11372, a unique and positively inotropic sodium-calcium exchanger/inhibitor

Otsomaa L, Levijoki J, Wohlfahrt G, Chapman H, Koivisto AP, Syrjänen K, Koskelainen T, Peltokorpi SE, Finckenberg P, Heikkilä A, Abi-Gerges N, Ghetti A, Miller PE, Page G, Mervaala E, Nagy N, Kohajda Z, Jost N, Virág L, Varró A, Papp JG.

Br J Pharmacol. 2020 Sep 22. doi: 10.1111/bph.15257.

PMID: 32959887


Cardiac electrophysiological effects of ibuprofen in dog and rabbit ventricular preparations: Possible implication to enhanced proarrhythmic risk

Pászti BJ, Prorok J, Magyar T, Árpádffy-Lovas T, Györe B, Topál L, Gazdag P, Szlovák J, Naveed M, Jost N, Nagy N, Varró A, Virág L, Koncz I.

Can J Physiol Pharmacol. 2020 Sep 16. doi: 10.1139/cjpp-2020-0386.

PMID: 32937079


Chronic treatment with rofecoxib but not ischemic preconditioning of the myocardium ameliorates early intestinal damage following cardiac ischemia/reperfusion injury in rats.

László SB, Lázár B, Brenner GB, Makkos A, Balogh M, Al-Khrasani M, Hutka B, Mohammadzadeh A, Kemény Á, László T, Scheich B, Szabados T, Kenyeres É, Giricz Z, Bencsik P, Varga ZV, Novák J, Helyes Z, Ferdinandy P, Gyires K, Zádori ZS.

Biochem Pharmacol. 2020 Aug;178:114099. doi: 10.1016/j.bcp.2020.114099. Epub 2020 Jun 12.

PMID: 32540483


OEsophageal Ion Transport Mechanisms and Significance Under Pathological Conditions

Becskeházi E, Korsós MM, Erőss B, Hegyi P, Venglovecz V.

Front Physiol. 2020 Jul 16;11:855. doi: 10.3389/fphys.2020.00855.

PMID: 32765303


Different effect of amiodarone and dofetilide on the dispersion of repolarization between well coupled ventricular and Purkinje fibers

Árpádffy-Lovas T, Husti Z, Baczkó I, Varró A, Virág L.

Can J Physiol Pharmacol. 2020 Jul 21. doi: 10.1139/cjpp-2020-0234. Online ahead of print.

PMID: 32692935


Capsaicin-Sensitive Sensory Nerves and the TRPV1 Ion Channel in Cardiac Physiology and Pathologies

Szabados T, Gömöri K, Pálvölgyi L, Görbe A, Baczkó I, Helyes Z, Jancsó G, Ferdinandy P, Bencsik P.

Int J Mol Sci. 2020 Jun 23;21(12):4472. doi: 10.3390/ijms21124472.

PMID: 32586044


Ischaemic post-conditioning in rats: Responder and non-responder differ in transcriptome of mitochondrial proteins.

Schreckenberg R, Klein J, Kutsche HS, Schulz R, Gömöri K, Bencsik P, Benczik B, Ágg B, Sághy É, Ferdinandy P, Schlüter KD.

J Cell Mol Med. 2020 May;24(10):5528-5541. doi: 10.1111/jcmm.15209. Epub 2020 Apr 16.

PMID: 32297702


Swiprosin-1/EFhD-2 Expression in Cardiac Remodeling and Post-Infarct Repair: Effect of Ischemic Conditioning.

Giricz Z, Makkos A, Schreckenberg R, Pöling J, Lörchner H, Kiss K, Bencsik P, Braun T, Schulz R, Ferdinandy P, Schlüter KD.

Int J Mol Sci. 2020 May 9;21(9):3359. doi: 10.3390/ijms21093359.

PMID: 32397496


Electrical Restitution and Its Modifications by Antiarrhythmic Drugs in Undiseased Human Ventricular Muscle

Árpádffy-Lovas T, Baczkó I, Baláti B, Bitay M, Jost N, Lengyel C, Nagy N, Takács J, Varró A, Virág L.

Front Pharmacol. 2020 Apr 30;11:479. doi: 10.3389/fphar.2020.00479.

PMID: 32425771


The Cardiac Pacemaker Story-Fundamental Role of the Na+/Ca2+ Exchanger in Spontaneous Automaticity

Kohajda Z, Loewe A, Tóth N, Varró A, Nagy N.

Front Pharmacol. 2020 Apr 28;11:516. doi: 10.3389/fphar.2020.00516.

PMID: 32410993


Hidden Cardiotoxicity of Rofecoxib Can be Revealed in Experimental Models of Ischemia/Reperfusion.

Brenner GB, Makkos A, Nagy CT, Onódi Z, Sayour NV, Gergely TG, Kiss B, Görbe A, Sághy É, Zádori ZS, Lázár B, Baranyai T, Varga RS, Husti Z, Varró A, Tóthfalusi L, Schulz R, Baczkó I, Giricz Z, Ferdinandy P.

Cells. 2020 Feb 26;9(3):551. doi: 10.3390/cells9030551.

PMID: 32111102


Myocardial ischaemia reperfusion injury and cardioprotection in the presence of sensory neuropathy: Therapeutic options

Bencsik P, Gömöri K, Szabados T, Sántha P, Helyes Z, Jancsó G, Ferdinandy P, Görbe A.

Br J Pharmacol. 2020 Feb 14. doi: 10.1111/bph.15021. Online ahead of print.

PMID: 32059259


Novel Na+/Ca2+ Exchanger Inhibitor ORM-10962 Supports Coupled Function of Funny-Current and Na+/Ca2+ Exchanger in Pacemaking of Rabbit Sinus Node Tissue.

Kohajda Z, Tóth N, Szlovák J, Loewe A, Bitay G, Gazdag P, Prorok J, Jost N, Levijoki J, Pollesello P, Papp JG, Varró A, Nagy N.

Front Pharmacol. 2020 Jan 29;10:1632. doi: 10.3389/fphar.2019.01632.

PMID: 32063850


Examination of the Changes in Calcium Homeostasis in the Delayed Antiarrhythmic Effect of Sodium Nitrite

Demeter-Haludka V, Kovács M, Prorok J, Nagy N, Varró A, Végh Á

Int J Mol Sci. 2019 Nov 13;20(22):5687. doi: 10.3390/ijms20225687.

PMID: 31766239


The Novel Inodilator ORM-3819 Relaxes Isolated Porcine Coronary Arteries: Role of Voltage-Gated Potassium Channel Activation

Márton Z, Pataricza J, Pollesello P, Varró A, Papp JG.

J Cardiovasc Pharmacol. 2019 Sep;74(3):218-224.

PMID: 31356552


A Novel in situ Approach to Studying Pancreatic Ducts in Mice

Gál E, Dolenšek J, Stožer A, Pohorec V, Ébert A, Venglovecz V.

Front Physiol. 2019 Jul 24;10:938. doi: 10.3389/fphys.2019.00938.

PMID: 31396104


Definition of hidden drug cardiotoxicity: paradigm change in cardiac safety testing and its clinical implications.

Ferdinandy P, Baczkó I, Bencsik P, Giricz Z, Görbe A, Pacher P, Varga ZV, Varró A, Schulz R.

Eur Heart J. 2019 Jun 7;40(22):1771-1777. doi: 10.1093/eurheartj/ehy365.

PMID: 29982507


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